The Adverse Outcome Pathways (AOPs) in Predictive Toxicology Symposium begins at 3 pm. This symposium highlights the many purposes of AOP methodology for ‘predictive toxicology’ and integrating high throughput data and other in vitro data for developmental processes and toxicities. Individual topics will address a range of current issues including: the main information blocks needed to build AOPs; compilation of molecular initiating events (MIEs) and effects into AOP libraries for developing chemical categories that can inform quantitative structure activity relationship (QSAR) profilers; the use of AOPs to integrate data from in vitro profiling studies into systems models for dose predictivity; and the identification of research needs to fill data gaps in the cascade of events from MIE to adverse outcome.
Joint sessions with NBTS occur Sunday afternoon and include a special lecture at 2 pm by Pat Levitt on, Role of the Placenta in Fetal Brain Development and Functional Outcomes: Developmental Programming & Prenatal Environments. Following the lecture is the Prenatal Origins of Neuropsychiatric Disorders Symposium. Learn the latest theories and evidence on the prenatal origins of neuropsychiatric disorders. Speakers will summarize the growing body of experimental and human epidemiological evidence that prenatal infection or maternal immune activation in the absence of viral or bacterial agents cause fetal brain inflammatory reactions leading to neurotransmitter changes.