NIH Releases RFI on the Consideration of Sex as a Biological Variable in Research

NIH has released a Request for Information on the consideration of sex as a biological variable in research. NIH is seeking input from the research community on the following topics:

  • Whether consideration of sex as a biological variable is an issue affecting the reproducibility, rigor, and/or generalizability of research findings. 
  • Areas of science (e.g., cancer, neuroscience) or phases of research (e.g., basic, translational) conducted with animals that have the greatest opportunity or need for considering sex as a biological variable. 
  • Areas of science or phases of research conducted with cells and/or tissues that have the greatest opportunity or need for considering sex as a biological variable. 
  • Main impediments (e.g. scientific, technical, and other) to considering sex as a biological variable in research.
  • Ways in which NIH can facilitate the consideration of sex as a biological variable in NIH-supported research.
  • Any additional comments you would like to offer to NIH about the development of policies for considering sex as a biological variable in research involving animals, tissues, or cells.  

NIH will accept responses through October 13, 2014.  FASEB is working with the Animals in Research and Education Subcommittee and the Clinical and Translational Research Subcommittee to develop a letter to be sent to NIH on balancing sex in research which may be adapted to address some of the topics highlighted in the RFI.

 

1 Comment

sex prevalence and congenital anomalies

October 10, 2014 12:00 PM by Wladimir Wertelecki, M.D.

We find a consistent prevalence of females among infants with blastopathies (conjoined twins, sacral teratomas, cephalad NTD, NTD-omphalocle associations and microcephaly (isolated) in a region impacted by Chornobyl radiation in Ukraine. Elaboration on the subject are found in the August issue of the Congenital Anomalies Journal of the Japanese Soc. of Teratology. 

W. Wertelecki, M.D.   genfir3@gmail.com l

Recent Stories
FDA Launches Predictive Toxicology Roadmap

PODCAST: Secrets of the Human Brain Revealed: Development, Disease & the Zika Virus

FASEB Report: Reforming Animal Research Regulations: Workshop Recommendations to Reduce Regulatory Burden