Congratulations to Marilyn H. Silva, PhD, DABT, and her team of researchers, whose paper, A Comparison of ToxCast Test Results with In Vivo and Other In Vitro Endpoints for Neuro, Endocrine, and Developmental Toxicities: A Case Study Using Endosulfan and Methidathion, has been recognized as the 2016 James G. Wilson Publication award! The Wilson Publication award is presented in recognition of the previous year’s best paper accepted or published in the journal Birth Defects Research.
Dr. Silva received a B.A. in Social Sciences from the University of California (U.C.), Berkeley (1972) and a B.A. in Biological Sciences from California State University, Sacramento (1975). She earned an M.S. in Veterinary Anatomy from U.C., Davis (1978) doing research on breast cancer with Robert Cardiff, M.D., Ph.D., and then a Ph.D. in Environmental Health Sciences from U.C. Berkeley (1983) continuing breast cancer research with Nicholas Petrakis, M.D. She was a post-doctoral fellow at U.C. Davis, in the laboratory of Bruce Hammock, Ph.D. in the Department of Toxicology (1984-1987) working on the purification and characterization of cytosolic epoxide hydrolase. Since then Dr. Silva has worked with the Department of Pesticide Regulation in the California Environmental Protection Agency, Sacramento, California, performing data review and pesticide risk assessments. She became board-certified as a Diplomate of the American Board of Toxicology in 1992 and has been a member of the Society of Toxicology since 1989 and the Teratology Society since 1999.
“Working on the paper was an interesting and challenging project,” said Dr. Silva. “We examined whether the well-established in vivo endpoints for two pesticides (endosulfan and methidathion) are concordant with results from biochemical pathway-specific ToxCast HTS assays, including zebrafish. We were primarily concerned with in vivo and in vitro ToxCast HTS endpoint comparisons relating to neuro- endocrine and developmental toxicity,” she explained.
Dr. Silva will accept the Wilson Publication Award and give a presentation on her team’s findings in San Antonio, TX, at the Teratology Society's 56th Annual Meeting on Sunday, June 26 at 2pm.