The March 2014 issue of Birth Defects Research Part A: Clinical and Molecular Teratology is available and you may access the table of contents online. Members who subscribe to BDR may access the full articles via the Teratology website using your member login information.
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Developmental Determinants and Changing Patterns of Respiratory Outcomes after Preterm Birth
Birth Defects Research (Part A) Special Issue
Co-edited by Simon J. Conway, PhD (Indiana University School of Medicine) and Steve Abman, MD (University of Colorado)
Premature babies with extremely low birth weight or infants who experience respiratory problems shortly after birth are at risk for bronchopulmonary dysplasia (BPD), formally called chronic lung disease of infancy. Typically, a child is not born with BPD, but along with asthma and cystic fibrosis, BPD is one of the most common chronic lung diseases in children. It is thought to develop as a consequence of prematurity and progressive lung inflammation and involves abnormal development of lung tissue often resulting in persistent lung function deficits. Although recent research approaches have significantly advanced our understanding of BPD pathogenesis, preventative therapies have largely failed to translate into significant reductions in BPD incidence as the global incidence of BPD has not declined over the past decade.
Although many of the implications of how these changes in BPD alter long-term pulmonary outcomes remain uncertain, this special issue of Birth Defects Research (Part A) brings together a diverse mix of new BPD reviews and primary data as a window into the remarkable progress and current state of the field. Chapters range from describing the changing epidemiology of BPD to discussion of several of the contemporary developmental mechanisms underlying altered lung development and the need to develop and incorporate direct measurements of functional gas exchange into clinically relevant animal models of inhibited alveolar development. Additional review articles provide up-to-date accounts of the spectrum of respiratory outcomes after preterm birth, a review the clinical evidence assessing the long-term impact of BPD on alveolar-capillary membrane function, and outline several future directions for the field.
As the Birth Defects Research (Part A) Clinical and Molecular Teratology journal is a significant comprehensive resource of original research and reviews in the field of birth defects and clinically-relevant research, this journal is the ideal venue for this Special Lung BPD issue.